Glucocorticoids for Croup

This week, as part of the Child Health Emergency Medicine Social Media Campaign, we are highlighting a Cochrane summary on glucocorticoids for the treatment of croup. This review was selected for the TREKK Evidence Repository on croup.

Key Messages:

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Related TREKK Resources:

Cochrane Summary:

Glucocorticoids for croup

Croup is common in children and is thought to be triggered after a viral infection. Croup causes swelling in the throat and windpipe (trachea) and causes hoarseness, a barking cough and noisy breathing. Croup usually gets better by itself but sometimes drugs are used to try and improve this condition. The review looked at trials of one type of steroid drug, glucocorticoids. Glucocorticoids can reduce the swelling and make it easier for the child to breathe. We found that glucocorticoids can start improving croup in children within six hours (14 studies, 1031 children). The effect lasts about 12 hours (eight studies, 532 children), lessens the need for other drugs, and shortens hospital stays by 12 hours (eight studies, 795 children). There were no adverse events associated with glucocorticoids. Additional studies are needed to determine the best dose of glucocorticoids.

Authors’ Conclusions:

Dexamethasone and budesonide are effective in relieving the symptoms of croup as early as six hours after treatment. Fewer return visits and/or (re)admissions are required and the length of time spent in hospital is decreased. Research is required to examine the most beneficial method for disseminating croup practice guidelines and to increase the uptake of evidence.

Check Out the Full Cochrane Systematic Review Below:

Russell, K.F., Liang, Y., O’Gorman, K., Johnson, D.W., Klassen, T.P. (2011). Glucocorticoids for croup. Cochrane Database Syst Rev, 1, CD001955. doi: 10.1002/14651858.CD001955.pub3

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This post is part of a weekly blog series highlighting pediatric emergency medicine (PEM) focused Cochrane summaries and other key resources selected by TREKK.

Published by arrangement with John Wiley & Sons.

Does a child’s cough sound like a barking seal? Could be croup

May 4, 2015 – This week’s blog post is also available from TREKK (Translating Emergency Knowledge for Kids).

“Michael’s barky cough startled Valerie from her sleep. For the last few nights, Valerie had not slept well as her two-year-old son was fighting a cold and had been up off and on with a fever and cough…She desperately hoped the coughing would stop…More barky coughing roused her from her thoughts. This time the cough frightened her. As she ran into his room, Michael seemed to be fighting for breath.”

Michael’s barky cough is a hallmark sign of croup. The cough that often occurs in the middle of the night, rousing parents from theirsleep, can be an intense and worrisome event for parents and their young children. However, croup is a well-defined condition with a strong evidence base supporting effective therapeutic management.

Croup, or laryngotracheobronchitis, is an illness that affects a child’s breathing. It is caused by many different viruses and most often occurs in the cooler fall and winter months. Croup occurs most commonly in children between 6 months and 3 years of age, but can occur in children of all ages. Croup is characterized by a barky cough that can start quite suddenly. Often the child will have a hoarse voice and difficulty breathing. You may hear a high pitched sound when the child breathes in (stridor). Croup is worse at night or when the child is lying flat. The symptoms occur predominately at night with improvement during the day. The barky cough and difficulty breathing usually resolve after a few nights, though occasionally they can last up to a week. Viruses that trigger croup symptoms are picked up from others, and usually spread through coughing, sneezing or contact with the mucous on tissues, toys or hands.

Doctors assess the severity of the child’s croup_story1_sep06-page-011symptoms by simply watching and listening. If children have an occasional barky cough, but no stridor, they have a mild case. If they have a frequent barky cough and easily heard stridor even while calm, they have a moderate case. If a child’s chest caves in as they breathe, in addition to a frequent barky cough and easily heard stridor, they have a severe case. When the child has severe symptoms they are most commonly very distressed and agitated. In most cases, the illness is mild and lasts a short time; however, in the most severe cases, a small number of children may require hospitalization and intubation (1).

Antibiotics do not work on croup because the infection is caused by a virus. However, there are a number of other treatment strategies. An overview of reviews compiled evidence to determine which treatment strategies were most effective. The overview brought together evidence from four systematic reviews that included 54 studies involving 4,710 children. The authors made the following conclusions:

  • Glucocorticoids are effective for treating children with mild croup in terms of reduction in symptoms, hospitalizations, and length of stay. Dexamethasone and budesonide were the most commonly studied and there was no evidence that one was superior to the other.
  • Both nebulized epinephrine and glucocorticoids are effective for children with moderate to severe croup that is accompanied by respiratory distress.
  • There was insufficient evidence to determine the effectiveness of heliox.
  • There is sufficient evidence showing that humidified air is not an effective treatment for croup.
  • Though there are no large scale surveillance studies published which focus on adverse effects from any of these treatments, randomized trials and systematic reviews of glucocorticoids, epinephrine, humidified air and heliox have not reported any significant adverse events.

Dr. David Johnson of the Alberta Children’s Hospital Research Institute has developed bottom line recommendations for treating croup in collaboration with Translating Emergency Knowledge for Kids (TREKK). The recommendations and other resources including clinical practice guidelines are available at trekk.ca. Dr. Johnson suggests:

“The vast majority of children with croup will resolve their barky cough and difficulty breathing within a few nights. While this will occur regardless of whether their child is treated or not, treatment with glucocorticoids helps reduce both children’s severity and duration of symptoms, allowing parents to relax and return to their normal daily routine sooner than they would otherwise.”

TREKK Resources:

References:

  1. Bjornson C, Russell K, Foisy M, Johnson DW. The Cochrane Library and the treatment of croup in children: an overview of reviews. Evidence-based Child Health: A Cochrane Review Journal 2010;5(4):1555-65.
  2. University of Alberta, Capital Health, Stollery Children’s Hospital. (2012). A Resourceful Father and His Internet Connections: Managing Croup at Home – Mild Croup [Brochure]. Edmonton, Canada.
  3. University of Alberta, Capital Health, Stollery Children’s Hospital. (2012). A Late Night Trip to the Emergency Department: Was It The Right Thing To Do? – Moderate Croup [Brochure]. Edmonton, Canada.
  4. University of Alberta, Capital Health, Stollery Children’s Hospital. (2012). Things We Take for Granted: A Mother’s Account of Her Child’s Struggle with Croup – Severe Croup [Brochure]. Edmonton, Canada.